Authors and their organizations：
Jiaxin Tian 1, Shifei Wei 1, Shiming Li 1, Hanruo Liu 1, Qing Zhang 1, Yan Cui 2, Jingyun Guo 2, Yequan Huang 2, Xuechuan Dong 2, Ningli Wang 11 Beijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Cener, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Lab. 100730, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University & Capital Medical University, Beijing Tongren Hospital, Beijing 100730, China
2 NIMO Ophthalmology Research Institute, Beijing 100176, China
Objective:
To explore the feasibility of using refractive compensation technology through optical imaging to measure the retinal refractive state.
Methods:
The refractive states of simulation eyes were measured by refractive compensation to retinal imaging. The diopters were measured for 10 times under different refractive states. The theoretical diopters, pattern plate distance, and the measured diopters were recorded at each time. Mean ± standard deviation was used to indicate the diopter value under different refractive states. The bias, which was defined as the difference between the the oretical diopter and the mean of the measured diopters, was calculated. The internal correlation coefficient (ICC) was analyzed for the consistency of the theoretical diopters and the measured diopters.
Results:
When the theoretical diopters of the simulation eye were set as -3.00 D, -2.00D, -1.00 D, 0.00 D, + 1.00 D, + 2. 00 D, and + 3.00 D, the measured diopters based on refractive compensation to retinal imaging at different refractive states were (2.90±0.07) D, (-1.98±0.07) D, (-0.96±0.07) D, (0.19±0.07) D, (1.18±0.10) D, (2.37±0.1) D, and (3.48±0.09) D, respectively; the biases were -0.01 D, -0.02 D, -0.04 D, -0.19 D, -0.18 D, -0.37 D, -0.48 D, respectively.Pearson correlation analysis showed the absolute values of the bias was positively correlated with the theoretical diopters(r=0.964, P<0.05). The mean of measured diopter in 10 times was in good agreement with the theoretical diopter. There was a statistical significance between results (ICC=0.997, P<0.05). When the simulation eyeswere set as -3.00 D, -2.00 D, and -1.00 D, which were simulated myopia, 30 times of measurements were made.The result showed the theoretical diopters of the simulation eye were in good agreement with the measured diopters with statistical significance (ICC=0.996, P<0.05). When the simulation eyes were set as + 3.00 D, + 2.00 D, and + 1.00 D, which were simulated hyperopia, 30 times of measurements were made. The result showed the theoretical diopters of the simulation eye were in good agreement with the measured diopters with statistical significance (ICC=0.984, P<0.05).
Conclusion:
The measurement of refractive state by refractive compensation to retinal imaging in the simulation eye is accurate, effective, and feasible.
